SAFETY OF CHROMIUM

Most of the concerns regarding the long-term safety of chromium supplementation arise from results of several cell culture studies using supraphysiological doses that suggested that chromium, particularly in the form of CrP, may increase DNA damage.

However, there is currently no evidence that chromium increases DNA damage in vivo. There have also been isolated reports of serious adverse events, including kidney failure, associated with CrP treatment, but the relationship of chromium to these events is not clear.

Recent reviews of the safety of CrP by the Institute of Medicine (84) and by Berner et al. have concluded that CrP is safe. Results from controlled clinical trials have shown that treatment with chromium at doses up to 1,000 µg/day and for periods as long as 64 months does not result in any toxic effects.

ADDITIONAL:

Figure Above - Effects of chromium supplementation on insulin sensitivity in overweight subjects with a family history of diabetes treated for 8 months with 1,000 µg/day CrP (64). Data are means ± SD. *P < 0.05, **P < 0.005 versus baseline.
Conclusion : Data show that insulin sensitivity was increased for the group patient which is supplied with chromium.