RECOGNITION : GT&F CLINICAL TEST SHOW POSITIVE RESULT FOR DIABETES

Randomized, double-blind, placebo-controlled clinical test

Leader : Dr. Tai Tung-Yuan

• Former Principle of Taiwan National University College of Medicine

• Renown Taiwan Diabetes Specialist

• Director of Taiwan Diabetes Association

Clinical Trial Team :
1. Taiwan National University Hospital, participant Dr. Zhuang Li Meng specialist in Molecular Virology
2.Tri-Service General Hospital, participant Dr. Kuo Xi Wen specialist in Metabolism
3.Taichung Veterans General Hospital, participant Dr. Hsu Hui Heng specialist in Metabolism
4. National Cheng-Kung University Hospital, participant Dr. Wu Da Ren specialist in Metabolism
5. Jian Ya Biotechnology Cooperation, participant Dr. Chang Qi Tai specialist in New Medicine Exploitation

Hospitals:

This clinical test was carried out in four renowned hospitals in Taiwan:

• National Cheng-Kung University Hospital

• National Taiwan University Hospital

• Tri-Service General Hospital

• Taichung Veterans General Hospital

This clinical test has shown that GT&F® Milk Powder is effective in lowering fasting plasma glucose in diabetes patients.

Clinical Test Results: (published in The 25 th Annual Meeting of The Endocrinology Society and The Diabetes Association of The R.O.C. 2004)

RESEARCH FINDING
The followings are the status of various R&D work and product testing conducted on GT&F Milk Powder:

1. Content Analysis Completed: Samples from 3 different batches of milk powder produced were sent for ingredient and quality control analysis. The analysis was conducted and report was issued by the Food Industry Development Research Centre.

2. Product Stability Analysis Completed: The analysis was conducted by the physiology lab in the Veterinary faculty of the Taiwan Chung-Hsing University and GMP Chinese Medicine Factory. The analysis results show that GT&F Milk Powder is stable in form and its drying and health supplement ingredient are meeting product stability standard.

3. Product Effectiveness Testing Completed: This testing was conducted by the physiology lab in the veterinary faculty of the Taiwan Chung-Hsing University. The product effectiveness testing had been completed.

4. Genetic Toxicity Testing Completed: This testing was conducted by the Food Industry Development Research Centre. Outcome of these tests proved that GT&F Milk Powder does not have genetic toxicity.

5. Oral Consumption Instant Toxicity Test Completed: This test was conducted by Agricultural Committee Agriculture Chemicals Testing Laboratory. Testing outcome showed that the sample had no toxic effect on laboratory rats. After 7 – 14 days, the test group rats have significant weight increase as compared to the rats from the control group. Analysis on internal organs of the test rats had indicated no harmful effect. The Oral Consumption Instant Toxicity Dosage (LD50) had shown to be at 5,000mg per kilogram body weight. This test confirmed that GT&F Milk Powder is not toxic.

6. 28-day Oral Toxicity Test Completed: This test was conducted by Agricultural Committee Agriculture Chemicals Testing Laboratory. Based on analysis on clinical symptoms, weight changes, food intake, eye checks, blood tests, serum analysis, etc. on the laboratory rats, no toxic reaction was indicated. The NOAEL dosage based on the 28-day oral toxicity test was determined to be 1000mg/kg of body weight. This test confirmed that GT&F Milk Powder is not toxic.

7. Human Clinical Trial Completed: This double-blind clinical trial was conducted in four major teaching hospitals in Taiwan: the Taiwan National University College of Medicine, Tai Chung Veterans General Hospital, National Cheng-Kong University Hospital and Army General Hospital. It was led by renown diabetes expert – Dr. Tai Dung-Yuan. Dr. Tai is the chairman of Taiwan Diabetic Association and former principal of the Taiwan National University College of Medicine. This trial was completed in 2004 and its final results had been publicized in July 2004. According to this trial, GT&F Milk Powder is effective in reducing blood glucose level and improves the symptoms of diabetes.

Innovation Incubator:
The research division of Maxluck Biotechnology Ltd. was officially located into the Innovation Incubator of National Chung-Hsing University in June 2000. The elite research team is led by Dr. Mao Jia-hung, PhD in endocrinology of Wisconsin University.