March - 25 - 2009
The protein TBC1D1 may be key in exercise-stimulated glucose transport, according to researchers from the University of Michigan School of Kinesiology. Prof. Gregory Cartee, with graduate student researcher Katsuhiko Funai, examined two proteins--TBC1D1 and AS160--that are believed to be important in glucose transport. When these proteins reacted with two different enzymes, the researchers found that TBC1D1 had the more important role in exercise-stimulated glucose transport. Focus on this protein could allow scientists to improve its function for people who are insulin-resistant. The next step for researchers is to find out how TBC1D1 promotes glucose transport, both during and after exercise. According to Cartee, most people with type 2 diabetes have muscle insulin resistance. "This doesn't cause diabetes by itself," he said, "but it's an essential component that contributes to type 2 diabetes."
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