GTF & Diabetes

What is Diabetes
Glucose is produced from the breakdown of food in the body’s digestive tract. When insulin secreted by the pancreas binds to insulin receptors, glucose is able to enter cells and either is converted to energy or stored within liver, muscle, and fat cells. But if there is insufficient insulin or if the body’s tissues respond poorly to insulin, glucose cannot be readily transformed into energy, and the blood sugar concentration will rise. An empty-stomach blood sugar concentration exceeding 140 mg/dl is the clinical definition of diabetes.

If the blood sugar concentration exceeds the limit that can be recycled by the kidneys (180 mg/dl), glucose will be excreted in the urine. It should be noted, however, that sugar in the urine is not necessarily caused by diabetes, while mild diabetes (sugar concentration of less than 180 mg/dl) will not necessarily cause sugar to appear in the urine. A physician’s professional diagnosis is needed in these cases.

What is Glucose Tolerance Factor (GTF)
Glucose Tolerance Factor (GTF) is found in our body tissues and cells. Its main function is to maintain normal glucose metabolism. It combines with insulin to transport blood glucose into our body cells.

GTF is a compound consist of trivalent chromium plus minerals, vitamin, and amino acids. Healthy people obtain trivalent chromium through diet, and chromium is then being converted to GTF to assist in glucose metabolism. However, overwork, pregnancy, obesity, old age, alcoholism, surgery, and disease can cause excessive loss of GTF in the body through secretion of urine and hence causing GTF deficiency.

Researches show that GTF plays an important role in glucose and lipid metabolism in human body, while intake of trivalent chromium is closely correlated to the risks of diabetes and cardiovascular diseases. A research of past 5 years shows that trivalent chromium can enhance utilization of glucose and has positive effects on various types of glucose intolerance, i.e. Type 1 diabetes mellitus, Type 2 diabetes mellitus, gestational diabetes and steroidal diabetes. The conditions of patients with diabetic neuro-pathological changes and poor glucose tolerance significantly improved when given recommended amount of chromium supplement. Trivalent chromium in the body stimulates the binding of insulin and insulin receptor, activates insulin receptor and improves insulin sensitivity. Trivalent chromium is an essential nutrient in the synthesis of GTF, and has positive effects on glucose, protein and lipid metabolisms in human and animals. Low chromium intake, coupled with poor eating habits of excessive sugar and lipid consumption result in severe chromium deficiency among current population. Therefore, adding chromium supplement in the daily diet helps patients with mild glucose intolerance and even patients with obvious diabetic symptoms to stimulate glucose metabolism, improve disease conditions and reduce complications..

As diabetic patients are under prolonged high-glucose state, their blood vessels experience severe damage, making the vessels fragile and hard to recover, resulting in complications of circulatory and nervous systems. Research showed that, in the presence of insulin, GTF could improve efficiency of insulin in glucose metabolism, reduce blood glucose concentration by 29% and triglycerides concentration by 56%. On the contrary, if the trivalent chromium in GTF is removed, it lost its ability in reducing blood glucose. Therefore, trivalent chromium is indispensable for glucose metabolism in our body.

The concentration of trivalent chromium in our body reduces with the increase of our age. In a clinical trial conducted by Dr. Stephen Davies in England, it was demonstrated that chromium in our serum reduces continuously from 0.5 mcg/mL when a person's age reaches 70. Chromium level in the serum of Type 2 diabetic patients is approximately 0.2 mcg/mL, significantly lower than the level of 0.5 mcg/mL in healthy people. These patients also experience higher chromium losses in urine. Several other conditions, such as over-work, pregnancy, obesity, old age, alcoholism, surgery or diseases, will cause depletion of trivalent chromium in the body, leading to trivalent chromium deficiency and reduced synthesis of GTF. Consequently, blood glucose cannot enter the cells easily and this will result in the clinical symptoms of type 2 diabetes.

GTF and Diabetes Relation Facts
Clinical researches have confirmed that the synergies between GTF and insulin could change various symptoms of diabetes. This is an essential factor to maintain normal glucose metabolism in the body. There is a direct correlation between onset of diabetes and trivalent chromium deficiency. Research in this area had been carried out by scientists for more than ten years and had shown that GTF deficiency could lead to diabetes. Supplementary of GTF and various nutrients beneficial to diabetes can improve insulin functionality, promote glucose metabolism in patients, and thus are considered as the latest complimentary treatment of diabetes.

All along diabetes is controlled using glucose-reducing drugs, such as sulfonylurea and biguanide derivatives. Although these two drugs have different mechanisms, both can only reduce blood glucose but cannot cure diabetes thoroughly. Thus the conditions of patients worsen each year. In the recent ten years, short-term insulin secretion enhancer, starch decomposition and absorption inhibitor and insulin sensitivity enhancer are added to enhance the control of diabetes. Their effects on controlling diabetes, however, are still limited. Current medical science researches on diabetes have turned towards the direction of strengthening the bioactivity of insulin and sensitivity of its receptor. Therefore, GTF offers a new direction for diabetes treatment.

Research in recent years found that the main cause of Type 2 diabetes is the reduction of insulin sensitivity. When our cells cannot utilize blood glucose efficiently, blood glucose stays higher and this stimulates increased secretion of insulin, causing high blood insulin symptoms. Low insulin sensitivity are mostly related to environment, diet, obesity, smoking and defective cell mechanisms. GTF can improve various symptoms of Type 2 diabetes, increase the sensitivity of insulin and insulin receptors, enhances the utilization of glucose by the cells, thus improve blood glucose metabolism. Supplementing GTF daily can increase the GTF level in the body and help normalizing glucose metabolism in diabetic patients. For healthy people, supplementing GTF has the effects of illness prevention and general health care.

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